Interferon-lambda receptor
Interferon-lambda receptor (IFNLR) is a type of receptor that is involved in the immune response of the body. It is a part of the interferon family of receptors and specifically binds to the interferon-lambda (IFN-λ) cytokines.
Structure[edit | edit source]
The interferon-lambda receptor is a heterodimeric receptor complex that is composed of two subunits: IFNLR1 and IL10RB. The IFNLR1 subunit is unique to the IFNLR, while the IL10RB subunit is shared with several other cytokine receptors.
Function[edit | edit source]
The primary function of the interferon-lambda receptor is to mediate the biological activities of the interferon-lambda cytokines. When IFN-λ binds to the IFNLR, it triggers a cascade of intracellular events that lead to the expression of numerous interferon-stimulated genes (ISGs). These ISGs have antiviral, antiproliferative, and immunomodulatory effects.
Clinical significance[edit | edit source]
The interferon-lambda receptor plays a crucial role in the immune response to viral infections, particularly in the epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Mutations in the genes encoding the IFNLR can lead to impaired antiviral immunity and increased susceptibility to viral infections.
In addition, the IFNLR is being investigated as a potential therapeutic target in various diseases, including hepatitis C, multiple sclerosis, and certain types of cancer.
See also[edit | edit source]
 | This immunology article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
