Interleukin-18 receptor
Interleukin-18 receptor (IL-18R) is a type of protein that is encoded by the IL18R1 gene in humans. It is a part of the interleukin receptor family, which plays a crucial role in the immune system.
Structure[edit | edit source]
The IL-18R is a heterodimeric receptor that is composed of two subunits: the alpha chain (IL-18Rα) and the beta chain (IL-18Rβ). The alpha chain is responsible for ligand binding, while the beta chain is involved in signal transduction.
Function[edit | edit source]
The primary function of the IL-18R is to bind to interleukin-18 (IL-18), a proinflammatory cytokine. This binding initiates a series of intracellular signaling events that lead to the activation of the nuclear factor kappa B (NF-κB) pathway, which is involved in the regulation of immune responses.
Clinical significance[edit | edit source]
Alterations in the IL-18R have been associated with several autoimmune diseases, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease. In addition, increased expression of IL-18R has been observed in certain types of cancer, suggesting a potential role in tumor progression.
See also[edit | edit source]
References[edit | edit source]
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