Interleukin-33

Interleukin-33 (IL-33) is a protein that in humans is encoded by the IL33 gene. It is a member of the interleukin family, a group of cytokines that play a crucial role in the immune system.

Function

IL-33 is a cytokine that binds to the ST2 receptor (IL1RL1). It is involved in inducing the production of type 2 cytokines from activated T cells, and can trigger the release of interleukin-4 (IL-4) and interleukin-13 (IL-13) from mast cells. This suggests that IL-33 plays a significant role in the immune response, particularly in the context of allergy and asthma.

Clinical significance

Research has shown that IL-33 plays a role in a variety of diseases. For example, it has been implicated in the pathogenesis of rheumatoid arthritis, asthma, and inflammatory bowel disease. It is also thought to play a role in the immune response to parasitic infections.

See also

• Interleukin
• Cytokine
• Immune system
• Allergy
• Asthma

References

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