Interleukin 1 receptor-like 1

Interleukin 1 receptor-like 1 (also known as IL1RL1) is a protein that in humans is encoded by the IL1RL1 gene. It is a member of the Interleukin-1 receptor family and is involved in the process of inflammation and immune responses.

Function

The protein encoded by the IL1RL1 gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related structurally to the interleukin 1 receptor accessory protein. The function of IL1RL1 is not known. However, it is thought to be involved in many immune responses.

Clinical significance

Alterations in the function of IL1RL1 may be involved in the pathogenesis of various diseases, including asthma, eczema, and allergic rhinitis. Studies have also suggested a role for IL1RL1 in the development of autoimmune diseases, including rheumatoid arthritis and systemic lupus erythematosus.

Interactions

IL1RL1 has been shown to interact with MYD88, a universal adapter protein that is an essential component of the Toll-like receptor and IL-1 receptor signaling pathways.

See also

• Interleukin 1
• Interleukin 1 receptor
• Interleukin 1 receptor accessory protein

References

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