Interleukin 20 receptor, alpha subunit

Interleukin 20 receptor, alpha subunit (IL20RA) is a type of protein that in humans is encoded by the IL20RA gene. It is a part of the interleukin receptor family, specifically the interleukin 20 (IL-20) receptor complex.

Function

The IL20RA is a subunit of the receptor for IL20, IL19 and IL24. It is involved in the JAK-STAT signaling pathway, which is a critical component of the immune response. The receptor is expressed in skin, lung, and reproductive tissues, where it plays a role in the regulation of skin homeostasis and inflammation.

Structure

The IL20RA protein is a type I transmembrane protein that is part of the class II cytokine receptor family. It forms a heterodimeric receptor complex with the IL20RB protein, which is necessary for signal transduction.

Clinical significance

Mutations in the IL20RA gene have been associated with autoimmune diseases such as psoriasis and rheumatoid arthritis. In addition, the receptor has been implicated in the pathogenesis of cancer, particularly in the promotion of tumor growth and angiogenesis.

See also

• Interleukin 20
• Interleukin 20 receptor, beta subunit
• JAK-STAT signaling pathway
• Autoimmune disease
• Psoriasis
• Rheumatoid arthritis

References

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