Intramyocellular lipids

Intramyocellular lipids (IMCL) are lipid droplets stored within skeletal muscle cells. They are a source of energy for the muscle during periods of high energy demand, such as during exercise. IMCLs are also implicated in insulin resistance and type 2 diabetes.

Etymology

The term "intramyocellular lipids" is derived from the Latin intra meaning "within", myo referring to muscle, and cellular referring to cells. Lipids is derived from the Greek lipos meaning "fat".

Function

Intramyocellular lipids serve as an energy source for the muscle. They are broken down into fatty acids and glycerol, which can be used in the process of cellular respiration to produce adenosine triphosphate (ATP), the main energy currency of the cell.

Role in disease

High levels of IMCLs are associated with insulin resistance and type 2 diabetes. This is thought to be due to the fact that high levels of fatty acids can interfere with the signaling pathways of insulin, leading to decreased insulin sensitivity.

Related terms

• Lipid droplet
• Skeletal muscle
• Insulin resistance
• Type 2 diabetes

See also

• Lipid metabolism
• Muscle metabolism