Intraneural perineurioma

An intraneural perineurioma is a rare benign tumor within the sheath of a single nerve that grows but typically does not recur or metastasize. These lesions are only composed of perineurial cells, cloned from a single cell. They are distinct from schwannoma and neurofibroma.

"Intraneural perineurioma is a neoplastic proliferation of perineurial cells with unique immunohistochemistry and ultrastructural features, and it is distinct from other onion bulb Schwann cell-derived entities. Despite harboring molecular abnormalities of the long arm of chromosome 22, intraneural perineurioma has not been associated with neurofibromatosis."

Further reading

• "Perineurioma: a distinctive and underrecognized peripheral nerve sheath neoplasm".Archives of Pathology & Laboratory Medicine.2007;131(4)

625–36.doi:[625:PADAUP2.0.CO;2 10.1043/1543-2165(2007)131[625:PADAUP]2.0.CO;2].PMID:17425397.

• "Intraneural reticular perineurioma of the hypoglossal nerve.".Head Neck..2009;31(6)

833–7.doi:10.1002/hed.20965.PMID:18972430.

• "Surgical removal of intraneural perineurioma arising in the brachial plexus using an interfascicular dissection technique".Arch Plast Surg.2014;41(3)

296–9.doi:10.5999/aps.2014.41.3.296.PMID:24883285.PMC:4037780.

• "Intraneural perineurioma. A clonal neoplasm associated with abnormalities of chromosome 22".Am J Clin Pathol.1995;103(6)

696–704.doi:10.1093/ajcp/103.6.696.PMID:7785653.