Ipronidazole

Ipronidazole

Ipronidazole is a nitroimidazole derivative that is used as an antiprotozoal agent. It is primarily used in veterinary medicine for the treatment of protozoan infections. Ipronidazole has been found to be particularly effective against Histomonas meleagridis, a protozoan parasite that causes histomoniasis (blackhead disease) in poultry.

Chemistry

Ipronidazole belongs to the class of organic compounds known as nitroimidazoles. These are organic compounds containing an imidazole ring which bears a nitro group. The imidazole ring of ipronidazole is substituted at position 1 with a nitro group and at position 2 with a propyl group.

Pharmacology

The antiprotozoal activity of ipronidazole is believed to be due to the reduction of its nitro group by anaerobic organisms. This reduction results in the formation of cytotoxic compounds that can bind to the DNA of the protozoan, causing DNA damage and cell death.

Veterinary Use

In veterinary medicine, ipronidazole is used for the treatment of protozoan infections in a variety of animal species. It is particularly effective against Histomonas meleagridis, a protozoan parasite that causes histomoniasis in poultry. Ipronidazole is administered orally, usually in the form of a medicated feed.

Safety

Ipronidazole is generally well tolerated in animals. However, it can cause some side effects, such as reduced feed intake and weight gain in poultry. In humans, exposure to ipronidazole can cause skin irritation and allergic reactions.

Regulation

In the United States, ipronidazole is approved by the Food and Drug Administration (FDA) for use in poultry. However, it is not approved for use in food-producing animals in the European Union due to concerns about potential residues in food.

See Also

• Nitroimidazole
• Antiprotozoal agent
• Histomoniasis

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