Irditoxin

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Irditoxin dimer 2h7z

Irditoxin is a potent neurotoxin found in the venom of certain species of snakes belonging to the genus Boiga. This toxin is primarily known for its ability to disrupt the normal function of the nervous system by targeting specific ion channels and receptors.

Structure and Function

Irditoxin is a member of the three-finger toxin (3FTx) family, which is characterized by its unique three-fingered structure. This structure allows the toxin to interact with various neurotransmitter receptors and ion channels, leading to the disruption of normal neural transmission. The primary targets of irditoxin are the nicotinic acetylcholine receptors (nAChRs) found at the neuromuscular junction.

Mechanism of Action

Irditoxin exerts its effects by binding to the nicotinic acetylcholine receptors on the post-synaptic membrane of the neuromuscular junction. This binding inhibits the normal action of acetylcholine, a neurotransmitter responsible for muscle contraction. As a result, the toxin causes paralysis by preventing the transmission of nerve impulses to the muscles.

Clinical Significance

The study of irditoxin and other snake venom toxins has significant implications for medical research and the development of new therapeutic agents. Understanding the mechanisms by which these toxins operate can lead to the development of novel treatments for conditions such as neuromuscular disorders and chronic pain.

Related Toxins

Irditoxin is part of a broader category of snake venom toxins that includes other neurotoxins such as alpha-bungarotoxin, cobratoxin, and dendrotoxin. These toxins share similar mechanisms of action but differ in their specific targets and effects.

See Also

• Snake venom
• Neurotoxin
• Three-finger toxin
• Nicotinic acetylcholine receptor
• Neuromuscular junction
• Paralysis