Isocitric acid
Isocitric acid is a metabolite in the tricarboxylic acid cycle, also known as the Krebs cycle or the citric acid cycle. It is an isomer of citric acid and is formed through the action of the enzyme aconitase on citric acid.
Structure and properties[edit | edit source]
Isocitric acid is a chiral compound that exists in two forms, D-Isocitric acid and L-Isocitric acid. The L-isomer is the one that is involved in the Krebs cycle. It is a colorless compound and is soluble in water.
Role in the Krebs cycle[edit | edit source]
In the Krebs cycle, isocitric acid is produced from citric acid by the enzyme aconitase. This is then converted into alpha-ketoglutaric acid by the enzyme isocitrate dehydrogenase, in a reaction that also produces NADH and carbon dioxide.
Industrial uses[edit | edit source]
Isocitric acid is used in the food industry as a flavor enhancer and a preservative. It is also used in the pharmaceutical industry in the production of certain medicines.
Health effects[edit | edit source]
Isocitric acid is generally considered safe for consumption. However, excessive consumption can lead to acidosis, a condition characterized by an excess of acid in the body fluids.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
