Isodisomy

Isodisomy
Synonyms	Uniparental isodisomy
Pronounce	N/A
Specialty	N/A
Symptoms	Developmental delay, growth abnormalities, congenital anomalies
Complications	Genetic disorders
Onset	Prenatal
Duration	Lifelong
Types	N/A
Causes	Uniparental disomy, nondisjunction
Risks	Advanced maternal age, assisted reproductive technology
Diagnosis	Genetic testing, karyotyping
Differential diagnosis	Heterodisomy, trisomy
Prevention	N/A
Treatment	Symptomatic treatment, genetic counseling
Medication	N/A
Prognosis	Varies depending on associated conditions
Frequency	Rare
Deaths	N/A

Isodisomy is a type of uniparental disomy where two copies of a chromosome or part of a chromosome are inherited from one parent. This can occur as a result of meiotic non-disjunction or post-zygotic chromosomal duplication. Isodisomy can lead to a number of genetic disorders, depending on the specific chromosomes involved.

Causes

Isodisomy can occur as a result of two main processes: meiotic non-disjunction and post-zygotic chromosomal duplication. In meiotic non-disjunction, both copies of a chromosome from one parent are passed on to the offspring. This can occur in either the first or second division of meiosis. Post-zygotic chromosomal duplication occurs after fertilization, when a single copy of a chromosome duplicates itself to produce two identical copies.

Genetic Disorders

Isodisomy can lead to a number of genetic disorders, depending on the specific chromosomes involved. These can include Prader-Willi syndrome, Angelman syndrome, and Beckwith-Wiedemann syndrome, among others. In these disorders, the presence of two identical copies of a chromosome from one parent leads to an imbalance in genetic material, which can disrupt normal development and lead to a range of health problems.

See Also

• Uniparental disomy
• Genetic disorder
• Chromosome
• Meiosis