Isodisomy
Isodisomy is a type of uniparental disomy where two copies of a chromosome or part of a chromosome are inherited from one parent. This can occur as a result of meiotic non-disjunction or post-zygotic chromosomal duplication. Isodisomy can lead to a number of genetic disorders, depending on the specific chromosomes involved.
Causes[edit | edit source]
Isodisomy can occur as a result of two main processes: meiotic non-disjunction and post-zygotic chromosomal duplication.
In meiotic non-disjunction, both copies of a chromosome from one parent are passed on to the offspring. This can occur in either the first or second division of meiosis.
Post-zygotic chromosomal duplication occurs after fertilization, when a single copy of a chromosome duplicates itself to produce two identical copies.
Genetic Disorders[edit | edit source]
Isodisomy can lead to a number of genetic disorders, depending on the specific chromosomes involved. These can include Prader-Willi syndrome, Angelman syndrome, and Beckwith-Wiedemann syndrome, among others.
In these disorders, the presence of two identical copies of a chromosome from one parent leads to an imbalance in genetic material, which can disrupt normal development and lead to a range of health problems.
See Also[edit | edit source]
References[edit | edit source]
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