Isoguvacine
Isoguvacine[edit | edit source]
Isoguvacine is a chemical compound that acts as a selective agonist for the GABA_A receptor, a subtype of the gamma-aminobutyric acid (GABA) receptor. It is primarily used in scientific research to study the function of GABA_A receptors and their role in the central nervous system.
Chemical Properties[edit | edit source]
Isoguvacine is a derivative of GABA, the main inhibitory neurotransmitter in the mammalian central nervous system. The chemical structure of isoguvacine allows it to bind selectively to the GABA_A receptor, mimicking the action of GABA itself. This selectivity makes isoguvacine a valuable tool in neuropharmacology.
Mechanism of Action[edit | edit source]
Isoguvacine functions by binding to the GABA_A receptor, which is a ligand-gated ion channel. Upon binding, isoguvacine induces a conformational change in the receptor, leading to the opening of the ion channel. This allows the influx of chloride ions into the neuron, resulting in hyperpolarization of the neuronal membrane and inhibition of neuronal firing. This mechanism is similar to that of GABA, but isoguvacine is used to specifically study the GABA_A receptor without affecting other GABA receptor subtypes.
Applications in Research[edit | edit source]
In research, isoguvacine is used to:
- Investigate the pharmacological properties of GABA_A receptors.
- Study the effects of GABAergic inhibition in various neurological and psychiatric disorders.
- Explore the role of GABA_A receptors in synaptic plasticity and neurotransmission.
Related Compounds[edit | edit source]
Isoguvacine is related to other GABA_A receptor agonists such as muscimol and gaboxadol. These compounds also bind to the GABA_A receptor but may have different affinities and efficacies, making them useful for comparative studies.
Safety and Handling[edit | edit source]
As with many research chemicals, isoguvacine should be handled with care. Appropriate safety measures, including the use of personal protective equipment and proper laboratory protocols, should be followed to prevent exposure and ensure safe handling.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
