Itolizumab
Itolizumab is a monoclonal antibody designed for the treatment of various autoimmune diseases. It is a first-in-class drug that selectively targets the CD6 molecule, a pan-T cell marker involved in co-stimulation, adhesion, and maturation of T cells. Itolizumab was developed by Biocon, a biopharmaceutical company based in India.
Mechanism of Action[edit | edit source]
Itolizumab binds to the CD6 molecule, which is present on the surface of T cells. By binding to CD6, itolizumab inhibits the proliferation and activation of T cells, which are involved in the pathogenesis of autoimmune diseases.
Clinical Uses[edit | edit source]
Itolizumab has been approved for the treatment of moderate to severe plaque psoriasis in India. It is also being studied for its potential use in other autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis.
Side Effects[edit | edit source]
The most common side effects of itolizumab include nausea, fatigue, headache, and infusion reactions. Serious side effects may include infections and allergic reactions.
Development and Approval[edit | edit source]
Itolizumab was developed by Biocon and received approval from the Drug Controller General of India (DCGI) in 2013 for the treatment of plaque psoriasis. In 2020, it received emergency use approval from the DCGI for the treatment of cytokine release syndrome in moderate to severe COVID-19 patients.
See Also[edit | edit source]
| Itolizumab Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
