JADE1

JADE1 (also known as Jade Family PHD Finger 1) is a protein that in humans is encoded by the JADE1 gene. It is a tumor suppressor gene that plays a crucial role in the regulation of cell cycle and apoptosis.

Function

The JADE1 protein is a part of the HBO1 complex, which is responsible for the acetylation of histones. This process is essential for the regulation of transcription and is crucial for cell cycle progression and DNA damage repair. The JADE1 protein also interacts with the BRCA1 tumor suppressor gene and is involved in BRCA1-mediated DNA repair.

Clinical Significance

Mutations in the JADE1 gene have been associated with various types of cancer, including breast cancer, ovarian cancer, and prostate cancer. The loss of JADE1 expression is often observed in cancer cells, suggesting that it may play a role in tumor suppression.

Research

Research on JADE1 is ongoing, with studies focusing on its role in cancer development and progression, as well as its potential as a therapeutic target for cancer treatment.

See Also

• BRCA1
• Tumor suppressor gene
• Histone acetylation and deacetylation