JWH-243
JWH-243 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent agonist of the cannabinoid receptors. It was first synthesized by John W. Huffman and his team at Clemson University as part of research into the structure-activity relationships of cannabinoids.
Chemical Structure and Properties[edit | edit source]
JWH-243 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. Its chemical structure consists of a naphthalene ring system linked to an indole group via a ketone bridge. The IUPAC name for JWH-243 is (4-methoxynaphthalen-1-yl)(1-pentyl-1H-indol-3-yl)methanone, and its molecular formula is C25H25NO2.
Pharmacology[edit | edit source]
JWH-243 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with a higher affinity for the CB1 receptor. This receptor is primarily found in the central nervous system and is responsible for the psychoactive effects of cannabinoids. The binding affinity of JWH-243 to these receptors is similar to that of other synthetic cannabinoids, making it a potent compound.
Legal Status[edit | edit source]
The legal status of JWH-243 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. It is often included in legislation targeting synthetic cannabinoids and "designer drugs."
Research and Applications[edit | edit source]
JWH-243, like other synthetic cannabinoids, has been used in scientific research to study the endocannabinoid system and the effects of cannabinoid receptor activation. However, due to its potency and potential for abuse, its use is restricted to controlled laboratory settings.
Health Effects and Risks[edit | edit source]
The use of JWH-243, particularly in unregulated products, poses significant health risks. These can include tachycardia, hypertension, hallucinations, and psychosis. Long-term effects are not well-studied, but there is concern about potential neurotoxicity and other adverse effects.
Also see[edit | edit source]
- Synthetic cannabinoids
- Cannabinoid receptor
- John W. Huffman
- Naphthoylindole
- CB1 receptor
- CB2 receptor
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