JWH-368

JWH-368.svg

JWH-368 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent agonist of the cannabinoid receptors. It was first synthesized by John W. Huffman and his team at Clemson University.

Chemical Structure

JWH-368 has a chemical structure that includes a naphthoylindole core. The full chemical name is 1-pentyl-3-(4-chloro-1-naphthoyl)indole. This structure is similar to other compounds in the JWH series, such as JWH-018 and JWH-073, but with a chlorine atom at the 4-position of the naphthoyl ring.

Pharmacology

JWH-368 acts as a potent agonist at the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including pain sensation, mood, and appetite.

Legal Status

The legal status of JWH-368 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. For example, in the United States, it is listed as a Schedule I controlled substance under the Controlled Substances Act.

Potential Effects and Risks

As with other synthetic cannabinoids, JWH-368 can produce effects similar to those of tetrahydrocannabinol (THC), the active component of cannabis. These effects may include euphoria, altered perception, and relaxation. However, synthetic cannabinoids like JWH-368 can also cause severe adverse effects, including tachycardia, hypertension, hallucinations, and psychosis.

Research and Applications

JWH-368, like other synthetic cannabinoids, has been used in scientific research to better understand the endocannabinoid system and the effects of cannabinoid receptor activation. However, due to its potential for abuse and adverse effects, its use is generally limited to controlled laboratory settings.

See Also

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman
• JWH-018
• JWH-073