Jay Houston Hoofnagle

Jay Houston Hoofnagle is an American gastroenterologist and hepatologist known for his contributions to the field of liver disease research, particularly in the study of hepatitis. Over his career, Hoofnagle has played a pivotal role in the development of treatments for hepatitis B and hepatitis C, significantly impacting patient care and outcomes.

Early Life and Education

Jay Houston Hoofnagle pursued his undergraduate education at Princeton University, where he majored in biology. Following his graduation, he attended the University of Rochester School of Medicine and Dentistry, earning his MD degree. His interest in liver diseases was sparked during his time in medical school, leading him to specialize in gastroenterology and hepatology during his residency and fellowship training.

Career

After completing his medical training, Hoofnagle joined the National Institutes of Health (NIH), where he has spent the majority of his career. At the NIH, he has held several key positions, including Director of the Liver Disease Research Branch within the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). His work at the NIH has focused on the clinical investigation of liver diseases, with a particular emphasis on viral hepatitis.

Hoofnagle's research has been instrumental in the development of antiviral therapies for hepatitis B and C. He was among the first to study the efficacy of interferon therapy in hepatitis B and played a significant role in the clinical trials that led to the approval of interferon and other antiviral drugs for the treatment of hepatitis C. His work has contributed to the transformation of hepatitis C from a chronic, untreatable infection to a curable disease for many patients.

Contributions to Hepatology

Hoofnagle's contributions to hepatology extend beyond his research on antiviral therapies. He has been involved in the study of drug-induced liver injury (DILI), autoimmune liver diseases, and the natural history of chronic liver disease. He has authored or co-authored over 500 scientific articles, reviews, and book chapters on these topics.

In recognition of his contributions to the field, Hoofnagle has received numerous awards and honors, including the American Association for the Study of Liver Diseases (AASLD) Distinguished Achievement Award.

Legacy

Jay Houston Hoofnagle's work has had a profound impact on the field of hepatology, improving the understanding and treatment of liver diseases. His research has not only advanced scientific knowledge but has also directly improved patient care and outcomes for those suffering from liver diseases, particularly viral hepatitis.

See Also

• Hepatitis B
• Hepatitis C
• Gastroenterology
• Hepatology
• National Institutes of Health

Resources

Latest articles - Jay Houston Hoofnagle

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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Jay Houston Hoofnagle for any updates.

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