Jedi2

Jedi2 is a gene that encodes the protein Jedi-2, also known as JEDI or Jedi-2/IL-17RB, in humans. This protein is a member of the Interleukin-17 receptor family and plays a crucial role in the immune response and inflammation.

Function

The Jedi2 gene is involved in the regulation of immune response and inflammation. It is known to interact with the Interleukin-17 (IL-17) family of cytokines, which are key players in both acute and chronic inflammatory responses. The Jedi2 protein acts as a receptor for these cytokines, triggering a cascade of events that lead to the activation of immune cells and the production of pro-inflammatory molecules.

Clinical significance

Alterations in the function of the Jedi2 gene or its protein product can lead to a variety of health conditions. For instance, overexpression of Jedi2 has been associated with several autoimmune diseases, including rheumatoid arthritis and psoriasis. On the other hand, underexpression of Jedi2 can result in a weakened immune response, making individuals more susceptible to infections.

Research

Research on the Jedi2 gene and its protein product is ongoing, with scientists aiming to better understand its role in the immune response and inflammation. This could potentially lead to the development of new treatments for diseases associated with inflammation and immune dysfunction.

See also

• Interleukin-17 receptor
• Immune response
• Inflammation
• Rheumatoid arthritis
• Psoriasis