KIF20A

KIF20A (Kinesin Family Member 20A), also known as MKLP2 (Mitotic Kinesin-Like Protein 2), is a protein that in humans is encoded by the KIF20A gene. This protein is a member of the kinesin-like protein family and plays a critical role in mitosis, specifically in the formation of the mitotic spindle and in the completion of cytokinesis. KIF20A is essential for the proper distribution of chromosomes during cell division, ensuring that each daughter cell receives an accurate copy of the genome.

Function

KIF20A is a motor protein that moves along microtubules, using energy derived from ATP hydrolysis. It is involved in the transport of various cellular components, including chromosomes and vesicles. During mitosis, KIF20A is particularly important for the assembly and maintenance of the mitotic spindle, a structure made of microtubules that segregates chromosomes into the daughter cells. Additionally, KIF20A plays a key role in cytokinesis, the final step of cell division, where it helps to form the cleavage furrow that divides the cell into two.

Gene

The KIF20A gene is located on chromosome 5 in humans. It consists of multiple exons that encode the different domains of the KIF20A protein, including the motor domain that allows it to move along microtubules and the tail domain that mediates interaction with cargo.

Clinical Significance

Alterations in the expression or function of KIF20A have been implicated in various types of cancer. Overexpression of KIF20A has been observed in pancreatic cancer, melanoma, and other malignancies, where it is associated with poor prognosis. The protein's role in cell division makes it a potential target for cancer therapy, as inhibiting KIF20A function could disrupt the proliferation of cancer cells.

In addition to cancer, research has suggested potential roles for KIF20A in other diseases, although these findings are still preliminary. Given its fundamental role in cell division, any dysfunction in KIF20A activity could potentially contribute to a wide range of pathological conditions.

Research

Ongoing research is focused on understanding the precise mechanisms by which KIF20A contributes to mitosis and cytokinesis, as well as exploring its role in disease. Studies are also investigating the potential of KIF20A as a biomarker for cancer diagnosis and prognosis, and as a target for novel therapeutic interventions.

See Also

• Kinesin
• Mitosis
• Cytokinesis
• Cancer
• Protein targeting

External Links

• NCBI Gene: KIF20A