KIR2DS4
KIR2DS4 is a gene that provides instructions for making a protein that plays a crucial role in the immune system. The KIR2DS4 gene is part of a family of KIR genes, which stand for "Killer cell Immunoglobulin-like Receptors". These genes are found on the surface of natural killer cells, which are a type of white blood cell that can kill certain types of cells in the body, such as cancer cells or cells infected with a virus.
Function[edit | edit source]
The KIR2DS4 gene encodes a protein that is a member of the killer cell immunoglobulin-like receptor (KIR) family. This family of proteins is primarily expressed on natural killer cells and plays a key role in controlling the immune response. The KIR2DS4 protein is a receptor that can bind to certain types of HLA class I molecules, which are proteins found on the surface of almost all cells in the body. This binding can influence the activity of the natural killer cell, potentially leading to the destruction of the target cell.
Clinical significance[edit | edit source]
Variations in the KIR2DS4 gene have been associated with susceptibility to certain diseases, including HIV infection and certain types of cancer. For example, some studies have suggested that individuals with certain KIR2DS4 gene variants may have a reduced risk of developing HIV infection. However, more research is needed to fully understand the role of KIR2DS4 in disease susceptibility.
See also[edit | edit source]
References[edit | edit source]
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