BRD4

Protein BRD4 PDB 2oss

BRD4

BRD4 is a protein that in humans is encoded by the BRD4 gene. It is a member of the bromodomain and extraterminal domain (BET) family of proteins. BRD4 plays a crucial role in regulating gene transcription by binding to acetylated histones and facilitating the recruitment of transcriptional machinery to specific genomic loci.

Structure

BRD4 consists of two bromodomains at the N-terminus and an extraterminal domain at the C-terminus. The bromodomains are responsible for recognizing and binding to acetylated lysine residues on histone proteins, while the extraterminal domain interacts with various transcription factors and coactivators.

Function

BRD4 functions as a transcriptional regulator by promoting the expression of genes involved in cell proliferation, differentiation, and survival. It also plays a role in the regulation of the cell cycle and is implicated in various cellular processes, including chromatin remodeling and DNA repair.

Clinical Significance

Aberrant expression of BRD4 has been associated with several human diseases, including cancer, cardiovascular disorders, and neurological conditions. Targeting BRD4 with small molecule inhibitors has emerged as a promising therapeutic strategy for the treatment of cancer and other diseases.

Interactions

BRD4 interacts with a variety of proteins involved in transcriptional regulation, chromatin remodeling, and signal transduction pathways. Some of its known binding partners include p53, MYC, and NF-κB.

Role in Cancer

Dysregulation of BRD4 has been implicated in the development and progression of various types of cancer, including leukemia, lymphoma, and solid tumors. Inhibition of BRD4 has shown promising results in preclinical studies and clinical trials as a potential treatment for cancer.