KLF13

KLF13 (Krüppel-like factor 13) is a protein that in humans is encoded by the KLF13 gene. It is a member of the Krüppel-like factor family of transcription factors.

Function

KLF13 is a transcription factor that plays a crucial role in the regulation of cardiac gene expression. It is involved in the pathophysiology of cardiovascular diseases, including hypertension and heart failure. KLF13 also plays a role in the regulation of immune response and inflammation, and has been implicated in the pathogenesis of autoimmune diseases.

Structure

The KLF13 protein is composed of 288 amino acids and has a molecular weight of approximately 32 kDa. It contains three C2H2-type zinc finger domains, which are involved in DNA binding.

Clinical significance

Alterations in the expression or function of KLF13 have been associated with several diseases. For example, overexpression of KLF13 has been observed in patients with rheumatoid arthritis, suggesting a potential role in the pathogenesis of this disease. In addition, mutations in the KLF13 gene have been linked to arrhythmia and sudden cardiac death.

Research

Research on KLF13 is ongoing, with studies focusing on its role in cardiovascular diseases, immune response, and inflammation. Understanding the function and regulation of KLF13 could potentially lead to the development of new therapeutic strategies for these conditions.