KLRB1

KLRB1 or CD161 is a gene that encodes the protein CD161 in humans. CD161 is a cell surface receptor expressed on natural killer cells and some T cells in the immune system. It plays a crucial role in the activation and function of these cells.

Function

The KLRB1 gene provides instructions for making a protein called CD161. This protein is found on the surface of certain cells in the immune system, including natural killer cells and a subset of T cells. CD161 acts as a receptor, which means it can attach (bind) to certain other proteins, triggering a series of chemical signals inside the cell. These signals play a role in the activation and function of natural killer cells and T cells.

Clinical significance

Alterations in the KLRB1 gene have been associated with various diseases. For instance, variations in this gene have been linked to susceptibility to inflammatory bowel disease and rheumatoid arthritis. Further research is needed to fully understand the role of KLRB1 in these and other conditions.

Research

Research into the KLRB1 gene and its encoded protein, CD161, is ongoing. Scientists are particularly interested in understanding how variations in this gene may contribute to disease susceptibility and the potential for targeted therapies.

See also

• Natural killer cell
• T cell
• Inflammatory bowel disease
• Rheumatoid arthritis