KMT2E

KMT2E (also known as MLL5) is a gene that encodes a protein involved in chromatin remodeling, a process that is crucial for the regulation of gene expression. The KMT2E protein is a member of the SET domain containing family of histone methyltransferases, which are responsible for the addition of methyl groups to histone proteins, thereby influencing gene expression.

Function

The KMT2E protein is involved in the regulation of hematopoiesis, the process by which blood cells are formed. It is also implicated in the control of cell cycle progression and cell differentiation. KMT2E is thought to play a role in the maintenance of hematopoietic stem cells, which are the cells that give rise to all other blood cells.

Clinical significance

Mutations in the KMT2E gene have been associated with a variety of diseases, including leukemia and other cancers. In particular, KMT2E has been implicated in the development of acute myeloid leukemia (AML), a type of cancer that affects the blood and bone marrow.

Research

Research into the function and role of KMT2E in disease is ongoing. Understanding the mechanisms by which KMT2E influences gene expression and cell behavior could lead to the development of new therapeutic strategies for treating diseases associated with mutations in this gene.

File:KMT2E gene location on human chromosome 7.png

Location of the KMT2E gene on human chromosome 7.

See also

• Histone methyltransferase
• Chromatin remodeling
• Gene expression
• Leukemia