Kallidinogenase

Kallidinogenase is an enzyme that is primarily involved in the kallikrein-kinin system, a complex system of proteins and peptides that play a crucial role in various physiological and pathological processes. Kallidinogenase is responsible for the conversion of kininogen to kallidin, a potent vasodilator and inflammatory mediator.

Function

Kallidinogenase, also known as tissue kallikrein, is a serine protease that cleaves kininogen to produce kallidin. Kallidin is then converted to bradykinin by the action of aminopeptidase. Both kallidin and bradykinin are part of the kinin group of proteins, which are known to have a wide range of effects in the body, including vasodilation, increased vascular permeability, and stimulation of pain receptors.

Clinical Significance

Due to its role in the production of kallidin and bradykinin, kallidinogenase has been implicated in a number of medical conditions. These include hypertension, inflammation, pain, and certain cardiovascular diseases. In addition, kallidinogenase has been studied for its potential therapeutic uses. For example, it has been used in Japan for the treatment of ischemic stroke.

Pharmacology

Kallidinogenase is available as a drug in some countries, including Japan, where it is used for the treatment of acute ischemic stroke. The drug is administered intravenously and is believed to work by improving blood flow to the brain and reducing inflammation.

See Also

• Kallikrein-kinin system
• Kininogen
• Bradykinin
• Ischemic stroke