Keratocystic odontogenic tumor
Keratocystic odontogenic tumor (KCOT) is a benign neoplasm that originates from the dental lamina. It is a unique entity due to its aggressive behavior, high recurrence rate, and characteristic histopathological findings.
Etiology[edit | edit source]
The etiology of KCOT is not completely understood. However, it is believed to be associated with mutations in the PTCH1 gene. This gene is also associated with nevoid basal cell carcinoma syndrome (NBCCS), a condition that increases the risk of developing several types of cancer, including KCOT.
Clinical Features[edit | edit source]
KCOTs are often asymptomatic and are usually discovered during routine dental radiographic examinations. When symptoms do occur, they may include pain, swelling, and the presence of a cyst or lump in the mouth or jaw.
Diagnosis[edit | edit source]
The diagnosis of KCOT is based on a combination of clinical, radiographic, and histopathological findings. Radiographically, KCOTs often present as a unilocular or multilocular radiolucent lesion with well-defined borders. Histopathologically, KCOTs are characterized by a thin, uniform epithelial lining with a corrugated parakeratin surface and a prominent basal cell layer.
Treatment[edit | edit source]
The treatment of KCOTs is controversial due to their high recurrence rate. Treatment options include conservative methods such as enucleation and curettage, as well as more aggressive methods such as resection.
Prognosis[edit | edit source]
The prognosis of KCOTs is generally good, but the high recurrence rate can lead to significant morbidity. Regular follow-up is essential to monitor for recurrence.
See Also[edit | edit source]
References[edit | edit source]
| Keratocystic odontogenic tumor Resources | |
|---|---|
|
 |
External Links[edit | edit source]
- Keratocystic odontogenic tumor: A 10-year retrospective study of 83 cases in an Iranian population (Journal of Oral and Maxillofacial Pathology)
- Keratocystic Odontogenic Tumor (GeneReviews)
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
