KiSS1-derived peptide receptor

KiSS1-derived peptide receptor (also known as GPR54 or KISS1R) is a G protein-coupled receptor that in humans is encoded by the KISS1R gene. It is a key player in the regulation of puberty and sexual maturation.

Function

The KiSS1-derived peptide receptor is a G protein-coupled receptor that binds to a family of peptides known as kisspeptins, which are derived from the KiSS1 gene. The interaction between kisspeptins and their receptor plays a crucial role in the regulation of the hypothalamic-pituitary-gonadal axis, which controls sexual maturation and reproductive function.

Clinical significance

Mutations in the KISS1R gene can lead to hypogonadotropic hypogonadism, a condition characterized by delayed or absent puberty and infertility. In addition, the KiSS1-derived peptide receptor has been implicated in the regulation of metastasis in various types of cancer, including breast cancer and melanoma.

See also

• Kisspeptin
• G protein-coupled receptor
• Hypothalamic-pituitary-gonadal axis
• Hypogonadotropic hypogonadism

References

‎ ‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian