KiSS1-derived peptide receptor
KiSS1-derived peptide receptor (also known as GPR54 or KISS1R) is a G protein-coupled receptor that in humans is encoded by the KISS1R gene. It is a key player in the regulation of puberty and sexual maturation.
Function[edit | edit source]
The KiSS1-derived peptide receptor is a G protein-coupled receptor that binds to a family of peptides known as kisspeptins, which are derived from the KiSS1 gene. The interaction between kisspeptins and their receptor plays a crucial role in the regulation of the hypothalamic-pituitary-gonadal axis, which controls sexual maturation and reproductive function.
Clinical significance[edit | edit source]
Mutations in the KISS1R gene can lead to hypogonadotropic hypogonadism, a condition characterized by delayed or absent puberty and infertility. In addition, the KiSS1-derived peptide receptor has been implicated in the regulation of metastasis in various types of cancer, including breast cancer and melanoma.
See also[edit | edit source]
- Kisspeptin
- G protein-coupled receptor
- Hypothalamic-pituitary-gonadal axis
- Hypogonadotropic hypogonadism
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
