Klebsiella granulomatis

Klebsiella granulomatis is a bacterial species in the Klebsiella genus of the Enterobacteriaceae family. It is the causative agent of granuloma inguinale, a sexually transmitted infection.

Taxonomy[edit | edit source]

The bacterium was first described in 1913 by Charles Donovan, and was initially named Donovanosis granulomatis. It was later reclassified into the Klebsiella genus due to its similar characteristics with other species in this genus.

Characteristics[edit | edit source]

Klebsiella granulomatis is a Gram-negative, rod-shaped bacterium. It is non-motile and does not form spores. The bacterium is oxidase negative and catalase positive.

Pathogenesis[edit | edit source]

Klebsiella granulomatis causes granuloma inguinale, a chronic and progressive sexually transmitted infection. The bacterium infects the skin and mucous membranes, leading to the formation of granulomatous lesions. The disease is most common in tropical and subtropical regions.

Diagnosis[edit | edit source]

Diagnosis of granuloma inguinale is typically made by identifying Klebsiella granulomatis in tissue samples from the lesions. The bacterium can be visualized using Wright's stain or Giemsa stain.

Treatment[edit | edit source]

Treatment for granuloma inguinale typically involves antibiotics, such as doxycycline or azithromycin. Early treatment can prevent complications, such as scarring and genital mutilation.

Epidemiology[edit | edit source]

Granuloma inguinale is rare in most parts of the world, but is more common in certain tropical and subtropical regions, including parts of India, Papua New Guinea, and the Caribbean.