L-655,708
L-655,708 is a drug that acts as a selective inverse agonist of the alpha-5 subunit of the GABAA receptor. It is used in scientific research and has no medical use in humans, but is legal for use in research settings.
Pharmacology[edit | edit source]
L-655,708 is a selective inverse agonist of the alpha-5 subunit of the GABAA receptor, which is a subtype of the GABAA receptor that is expressed in high levels in the hippocampus and related areas of the brain. This makes it useful for research into the role of this receptor subtype in learning, memory, and other cognitive functions.
Uses[edit | edit source]
L-655,708 is used in scientific research to investigate the role of the alpha-5 subunit of the GABAA receptor in various processes. It has been used in studies investigating the role of this receptor subtype in learning and memory, and has also been used to investigate the potential for drugs targeting this receptor subtype to be used in the treatment of cognitive disorders such as Alzheimer's disease and schizophrenia.
Side Effects[edit | edit source]
As a research chemical, L-655,708 is not used in humans and therefore its side effects are not well known. However, as an inverse agonist of the GABAA receptor, it is likely to have similar side effects to other drugs that modulate this receptor, such as anxiety, insomnia, and potentially seizures in high doses.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
