L-687,414

Chemical compound

Chemical structure of L-687,414

L-687,414 is a chemical compound that acts as a potent and selective antagonist of the NMDA receptor. It is primarily used in scientific research to study the role of NMDA receptors in various physiological and pathological processes.

Chemical Properties

L-687,414 is a synthetic compound with a complex chemical structure. It is characterized by its ability to bind to the NMDA receptor, a type of glutamate receptor that plays a crucial role in synaptic plasticity and memory function.

Mechanism of Action

L-687,414 functions as an NMDA receptor antagonist. By binding to the receptor, it inhibits the action of glutamate, the primary excitatory neurotransmitter in the central nervous system. This inhibition can help in understanding the role of NMDA receptors in neurotransmission and neurodegenerative diseases.

Research Applications

L-687,414 is used extensively in neuroscience research. It helps in elucidating the mechanisms underlying excitotoxicity, a process that can lead to neuronal damage and is implicated in conditions such as stroke, epilepsy, and Alzheimer's disease.

Pharmacological Effects

As an NMDA receptor antagonist, L-687,414 can modulate synaptic transmission and has potential therapeutic implications for disorders involving excessive NMDA receptor activity. However, its use is primarily limited to research settings.

Safety and Handling

In laboratory settings, L-687,414 should be handled with care, following standard safety protocols for chemical compounds. It is important to use appropriate personal protective equipment and work in a well-ventilated area.

Related Pages

• NMDA receptor
• Glutamate receptor
• Neurotransmitter
• Synaptic plasticity