LPAR6

LPAR6 (Lysophosphatidic acid receptor 6) is a G protein-coupled receptor (GPCR) that is encoded by the LPAR6 gene in humans. This receptor is part of the lysophospholipid receptor family, which is involved in various cellular processes, including cell proliferation, migration, and survival.

Function

LPAR6 is primarily activated by lysophosphatidic acid (LPA), a bioactive lipid that mediates diverse biological functions. The receptor is known to play a crucial role in the regulation of hair growth and skin homeostasis. Mutations in the LPAR6 gene have been associated with hypotrichosis and other hair growth disorders.

Clinical Significance

Mutations in the LPAR6 gene can lead to autosomal recessive hypotrichosis, a condition characterized by sparse hair growth on the scalp and body. This condition is part of a group of disorders known as ectodermal dysplasias, which affect the development of the skin, hair, nails, and teeth.

Pathways

LPAR6 is involved in several signaling pathways, including the RhoA and Ras pathways, which are important for cytoskeletal organization and cell motility. The receptor's activation can lead to the phosphorylation of downstream targets, influencing various cellular responses.

Research

Ongoing research is focused on understanding the precise mechanisms by which LPAR6 influences hair growth and its potential role in other physiological and pathological processes. Studies are also exploring the therapeutic potential of targeting LPAR6 in conditions such as alopecia and cancer.

See also

• G protein-coupled receptor
• Lysophosphatidic acid
• Hypotrichosis

External links

• LPAR6 gene - NCBI
• LPAR6 - GeneCards