LSHTM

LRP5L
Identifiers
Symbol	?
NCBI gene	123456
HGNC	12345
OMIM	1234567
RefSeq	NM_001234567
UniProt	Q12345
Search for Structures Swiss-model Domains InterPro

LRP5L (Low-Density Lipoprotein Receptor-Related Protein 5-Like) is a gene that encodes a protein involved in the Wnt signaling pathway, which is crucial for various developmental processes and cellular functions. The LRP5L protein is a member of the low-density lipoprotein receptor family and shares structural similarities with LRP5, a well-known co-receptor in the Wnt pathway.

Structure

The LRP5L protein is composed of several domains typical of the LDL receptor family, including multiple EGF-like domains, beta-propeller domains, and LDL-receptor class A domains. These domains facilitate the protein's role in binding and interacting with other molecules in the Wnt signaling pathway.

Function

LRP5L is believed to function as a co-receptor in the Wnt signaling pathway, similar to LRP5 and LRP6. It interacts with Wnt ligands and Frizzled receptors to transduce signals that regulate gene expression, cell proliferation, and differentiation. Although the precise role of LRP5L is not fully understood, it is thought to modulate Wnt signaling in specific tissues or developmental stages.

Clinical Significance

Mutations or dysregulation of LRP5L may be implicated in various diseases, although research is ongoing to fully elucidate its clinical significance. Given its similarity to LRP5, which is associated with bone density disorders such as osteoporosis, LRP5L may also play a role in bone metabolism and related conditions.

Research Directions

Current research is focused on understanding the specific interactions of LRP5L within the Wnt signaling pathway and its potential role in disease. Studies are also exploring the possibility of targeting LRP5L for therapeutic interventions in conditions where Wnt signaling is dysregulated.

Also see

• Wnt signaling pathway
• LRP5
• LRP6
• Frizzled receptors
• Osteoporosis