LY-404,187
LY-404,187 is a pharmacological agent that belongs to the class of AMPAR potentiators. It is an ampakine compound that has been developed by Eli Lilly and Company, a multinational pharmaceutical company. LY-404,187 is known for its potential therapeutic applications in the treatment of various neurological disorders, including schizophrenia, depression, and Alzheimer's disease.
Pharmacology[edit | edit source]
LY-404,187 is an AMPAR potentiator, which means it enhances the activity of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), a type of ionotropic glutamate receptor. AMPARs are involved in fast synaptic transmission in the central nervous system (CNS). The potentiating effect of LY-404,187 on AMPARs is believed to improve neurotransmission and cognitive function.
Therapeutic Applications[edit | edit source]
LY-404,187 has been studied for its potential use in the treatment of several neurological disorders.
Schizophrenia[edit | edit source]
In schizophrenia, LY-404,187 may help to alleviate cognitive deficits associated with the disorder. This is due to its ability to potentiate AMPARs, which are thought to be hypoactive in individuals with schizophrenia.
Depression[edit | edit source]
LY-404,187 may also have potential as a treatment for depression. Studies have suggested that AMPAR potentiators can enhance the efficacy of antidepressants, potentially leading to improved treatment outcomes.
Alzheimer's Disease[edit | edit source]
In Alzheimer's disease, LY-404,187 may help to improve cognitive function and slow disease progression. This is due to its ability to enhance glutamatergic neurotransmission, which is often impaired in Alzheimer's disease.
Safety and Tolerability[edit | edit source]
Like all pharmacological agents, LY-404,187 has the potential to cause side effects. However, in preclinical studies, it has been shown to be well-tolerated, with a favorable safety profile.
See Also[edit | edit source]
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
