Laminin subunit gamma-3

Laminin subunit gamma-3 (also known as LAMC3) is a protein that in humans is encoded by the LAMC3 gene. Laminin subunit gamma-3 is a part of the laminin (large glycoprotein) family of proteins, which are an integral part of the structural scaffolding in almost every tissue of an organism.

Structure

The LAMC3 gene is located on the long (q) arm of chromosome 9 at position 34. The gene spans about 30,000 base pairs. The LAMC3 gene produces a protein that is a part of the laminin protein complex. The laminin protein complex is made up of three different types of proteins: alpha, beta, and gamma. The LAMC3 gene provides instructions for making a protein that is a part of the gamma subunit of the laminin protein complex.

Function

Laminin subunit gamma-3 is an essential component of the extracellular matrix in humans. It plays a crucial role in the development and function of the nervous system. It is involved in the process of neuronal migration, which is the method by which neurons travel from their birthplace to their final position in the brain and spinal cord.

Clinical significance

Mutations in the LAMC3 gene have been associated with a rare genetic disorder known as LAMA3-related junctional epidermolysis bullosa, which is characterized by severe skin blistering.

See also

• Laminin
• Extracellular matrix
• Neuronal migration