Latrophilin 2

Latrophilin 2 (LPHN2) is a protein that in humans is encoded by the LPHN2 gene. It is a member of the adhesion G protein-coupled receptor family, which is characterized by a long N-terminal extracellular region coupled to a 7-transmembrane domain via a GPCR-Autoproteolysis Inducing (GAIN) domain.

Function

Latrophilin 2 is a cell adhesion molecule that plays a crucial role in neuronal development and function. It is involved in the formation of synapses, the junctions where nerve cells communicate with each other. The protein is also thought to play a role in certain types of cancer, although research in this area is ongoing.

Structure

The LPHN2 gene is located on the short (p) arm of chromosome 1 at position 13.2. The protein encoded by this gene has a molecular mass of approximately 150 kDa and is composed of a large extracellular region, a seven-transmembrane domain, and a short C-terminal intracellular region.

Clinical significance

Mutations in the LPHN2 gene have been associated with various neurological disorders, including autism spectrum disorder and attention deficit hyperactivity disorder. In addition, overexpression of Latrophilin 2 has been observed in certain types of cancer, suggesting a potential role in tumor progression.

See also

• Latrophilin
• Adhesion G protein-coupled receptor

References

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