Lerdelimumab
Lerdelimumab (also known as CAT-152) is a human monoclonal antibody that was designed for the treatment of ocular surface diseases. It was developed by Cambridge Antibody Technology and was later licensed to Genzyme.
History[edit | edit source]
Lerdelimumab was developed by Cambridge Antibody Technology, a biotechnology company based in the United Kingdom. The company was later acquired by AstraZeneca, a multinational pharmaceutical and biopharmaceutical company. Lerdelimumab was licensed to Genzyme, a biotechnology company based in the United States, for further development and commercialization.
Mechanism of Action[edit | edit source]
Lerdelimumab is a human monoclonal antibody that targets TGF-beta 2, a cytokine that plays a crucial role in the development of fibrosis and scarring. By blocking the action of TGF-beta 2, Lerdelimumab can potentially prevent or reduce scarring and fibrosis in ocular surface diseases.
Clinical Trials[edit | edit source]
Lerdelimumab has undergone several clinical trials to evaluate its safety and efficacy in treating ocular surface diseases. However, the results of these trials have not been conclusive, and the development of Lerdelimumab has been discontinued.
Potential Applications[edit | edit source]
Despite the discontinuation of its development, Lerdelimumab has potential applications in the treatment of other diseases characterized by fibrosis and scarring, such as kidney disease, liver disease, and pulmonary fibrosis.
See Also[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
