Norepinephrine (medication)

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Overview of the medication Norepinephrine



Norepinephrine, also known as noradrenaline, is a medication used primarily in the treatment of severe hypotension and shock. It is a catecholamine with multiple roles, including functioning as a hormone and a neurotransmitter. In its medication form, norepinephrine is used to increase blood pressure in acute settings.

Mechanism of Action[edit | edit source]

Norepinephrine acts on both alpha and beta-adrenergic receptors, with a predominant effect on alpha-1 adrenergic receptors. This action leads to vasoconstriction, which increases peripheral vascular resistance and subsequently raises blood pressure. The beta-1 adrenergic effects also contribute to increased cardiac output by enhancing myocardial contractility.

Clinical Uses[edit | edit source]

Norepinephrine is primarily used in the management of:

It is administered intravenously, often in an intensive care setting, where continuous monitoring of the patient's cardiovascular status is possible.

Side Effects[edit | edit source]

Common side effects of norepinephrine include:

  • Hypertension
  • Reflex bradycardia
  • Arrhythmias
  • Peripheral ischemia

Due to its potent vasoconstrictive properties, norepinephrine can cause tissue necrosis if extravasation occurs. Therefore, it is often administered through a central venous catheter.

Contraindications[edit | edit source]

Norepinephrine should be used with caution in patients with:

  • Hypovolemia
  • Mesenteric or peripheral vascular thrombosis
  • Hyperthyroidism

Pharmacokinetics[edit | edit source]

Norepinephrine has a rapid onset of action, typically within minutes, and a short duration of action. It is metabolized by the liver and excreted in the urine.

History[edit | edit source]

Norepinephrine was first synthesized in the early 20th century and has been used in clinical practice for several decades. Its role in the management of shock and hypotension has been well established through numerous clinical trials and studies.

Also see[edit | edit source]

References[edit | edit source]

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