Levonorgestrel butyrate

Levonorgestrel Butyrate is a synthetic progestin that is used in hormonal contraception. It is a derivative of levonorgestrel, a hormone that is commonly used in many forms of contraception, including intrauterine devices (IUDs), contraceptive implants, and emergency contraception pills.

Chemical Structure and Properties

Levonorgestrel butyrate is a butyric acid ester of levonorgestrel. The addition of the butyrate group to the levonorgestrel molecule enhances its lipophilicity, which can potentially improve its absorption and distribution in the body. Like other progestins, levonorgestrel butyrate has a similar structure to progesterone, a natural hormone produced by the ovaries.

Mechanism of Action

Levonorgestrel butyrate works primarily by preventing ovulation. It does this by suppressing the secretion of gonadotropins, hormones that stimulate the ovaries to release an egg. In addition, levonorgestrel butyrate can also thicken the cervical mucus, making it more difficult for sperm to reach the egg, and alter the lining of the uterus, making it less likely for a fertilized egg to implant and develop.

Uses

Levonorgestrel butyrate is used in hormonal contraception. It can be used in various forms, including oral tablets, contraceptive implants, and IUDs. It is also used in combination with an estrogen in combined oral contraceptives.

Side Effects

Like other hormonal contraceptives, levonorgestrel butyrate can cause side effects. These can include nausea, headache, breast tenderness, and changes in menstrual bleeding patterns. In rare cases, it can also increase the risk of serious health problems, such as blood clots, stroke, and heart attack.

See Also

• Levonorgestrel
• Progestin
• Hormonal contraception
• Butyric acid