Lewis
Lewis is a term with multiple meanings in the field of medicine. It can refer to a gene known as the Lewis gene, or to a blood group system known as the Lewis system.
Lewis Gene[edit | edit source]
The Lewis gene is responsible for the production of the Lewis blood group system. It is located on chromosome 19 and is inherited in an autosomal dominant manner. The gene encodes a fucosyltransferase enzyme that adds a fucose sugar to precursor substances, resulting in the formation of the Lewis a and Lewis b antigens.
Lewis Blood Group System[edit | edit source]
The Lewis blood group system is a human blood group system based upon two genes on chromosome 19: FUT3 (the Lewis gene) and FUT2 (the Secretor gene). The system consists of two main antigens: Lewis a (Le^a) and Lewis b (Le^b). These antigens are not produced in the red blood cells, but in the body's tissues and secretions.
Lewis a[edit | edit source]
Lewis a (Le^a) is an antigen that is present in individuals who are non-secretors, meaning they do not secrete ABO antigens in their bodily fluids. The presence of this antigen can be determined through blood typing.
Lewis b[edit | edit source]
Lewis b (Le^b) is an antigen that is present in individuals who are secretors, meaning they secrete ABO antigens in their bodily fluids. The presence of this antigen can also be determined through blood typing.
Clinical Significance[edit | edit source]
The Lewis blood group system has clinical significance in transfusion medicine, immunohematology, and organ transplantation. It can also play a role in susceptibility to certain infections and diseases, such as Helicobacter pylori infection and Norovirus gastroenteritis.
See Also[edit | edit source]
Lewis Resources | |
---|---|
|
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD