Licofelone

Licofelone is a type of non-steroidal anti-inflammatory drug (NSAID) that is unique in its dual inhibition of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) enzymes. This dual inhibition is believed to reduce the gastrointestinal side effects often associated with NSAIDs, and potentially offer greater anti-inflammatory and analgesic efficacy.

Pharmacology

Licofelone acts by inhibiting the enzymes COX and 5-LOX. These enzymes are involved in the production of prostaglandins and leukotrienes respectively, which are substances that play a key role in inflammation and pain. By inhibiting these enzymes, licofelone reduces the production of these substances, thereby reducing inflammation and pain.

Clinical Use

Licofelone has been studied for use in the treatment of osteoarthritis. In clinical trials, it has shown to be effective in reducing pain and improving function in patients with this condition. It has also been studied for its potential use in the treatment of Alzheimer's disease, due to its ability to reduce inflammation in the brain.

Side Effects

The side effects of licofelone are similar to those of other NSAIDs. These can include gastrointestinal problems such as stomach pain, heartburn, and nausea. However, due to its dual inhibition of COX and 5-LOX, it is believed to have a lower risk of gastrointestinal side effects compared to other NSAIDs.

Development and Approval

Licofelone was developed by the pharmaceutical company Merckle GmbH, and is currently marketed under the brand name ML3000. It is not currently approved for use in the United States, but is approved in some other countries for the treatment of osteoarthritis.

See Also

• Non-steroidal anti-inflammatory drug
• Cyclooxygenase
• 5-lipoxygenase
• Osteoarthritis
• Alzheimer's disease