Lidoflazine

Lidoflazine is a vasodilator and coronary vasodilator that was used in the treatment of angina pectoris. It was withdrawn from the market due to its potential to cause serious ventricular arrhythmias.

Pharmacology[edit | edit source]

Lidoflazine is a calcium channel blocker that works by inhibiting the influx of calcium ions into cardiac and smooth muscle cells, thereby dilating the coronary and systemic arteries and decreasing myocardial oxygen demand. This results in an increase in blood flow to the heart and a decrease in the heart's workload, which can help to alleviate the symptoms of angina pectoris.

Side Effects[edit | edit source]

The most common side effects of lidoflazine include dizziness, headache, flushing, and nausea. In rare cases, it can cause serious ventricular arrhythmias, which led to its withdrawal from the market.

History[edit | edit source]

Lidoflazine was developed in the 1970s and was initially marketed as a treatment for angina pectoris. However, it was withdrawn from the market in the 1980s due to concerns about its safety, specifically its potential to cause serious ventricular arrhythmias.

See Also[edit | edit source]

Lidoflazine Resources
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