Ligelizumab
Ligelizumab is a monoclonal antibody designed for the treatment of chronic spontaneous urticaria (CSU). It is developed by Novartis, a Swiss multinational pharmaceutical company. Ligelizumab works by targeting and neutralizing immunoglobulin E (IgE), a type of antibody that plays a key role in allergic reactions.
Mechanism of Action[edit | edit source]
Ligelizumab is a monoclonal antibody that binds to IgE, preventing it from attaching to mast cells and basophils. This inhibits the release of inflammatory mediators like histamine, which are responsible for the symptoms of CSU.
Clinical Trials[edit | edit source]
Ligelizumab has undergone several clinical trials to evaluate its safety and efficacy. In a Phase IIb study, ligelizumab demonstrated superior efficacy compared to omalizumab, another IgE inhibitor, in patients with CSU who were unresponsive to antihistamines.
Approval[edit | edit source]
As of 2021, ligelizumab is not yet approved by the Food and Drug Administration (FDA) or the European Medicines Agency (EMA). However, it is under review by these regulatory bodies.
See Also[edit | edit source]
| Ligelizumab Resources | |
|---|---|
 |
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
