Lipase inhibitors

Lipase inhibitors are a class of drugs that aid in the treatment of obesity. They function by preventing the breakdown and absorption of fat in the body. This is achieved by inhibiting the function of lipase, an enzyme that breaks down fats in the intestines.

Mechanism of Action

Lipase inhibitors work by binding to and inactivating lipases in the gastrointestinal tract. These lipases, under normal circumstances, break down dietary fat into smaller components, so they can be absorbed into the bloodstream. By inhibiting the action of these enzymes, lipase inhibitors prevent the digestion and absorption of dietary fats, which are then excreted undigested.

Uses

Lipase inhibitors are primarily used in the management of obesity. They are often prescribed as part of an overall weight management program that includes a reduced calorie, low-fat diet and physical activity.

Side Effects

Common side effects of lipase inhibitors include gastrointestinal issues such as oily spotting from the rectum, flatulence, abdominal cramps, and fecal incontinence. These side effects are generally mild and temporary, but can be severe in some cases.

Examples

One of the most well-known lipase inhibitors is Orlistat, which is available both as a prescription drug and over the counter in a lower-dose formulation.

See Also

• Anti-obesity medication
• Digestive enzymes
• Orlistat