Liquid chromatography–mass spectrometry
Liquid chromatography–mass spectrometry (LC-MS) is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analysis capabilities of mass spectrometry (MS).
Overview[edit | edit source]
LC-MS is a powerful technique used for many applications which has very high sensitivity and selectivity. Generally its application is oriented towards the general detection and potential identification of chemicals in the presence of other chemicals (in a complex mixture).
Principle[edit | edit source]
LC-MS system is divided into three parts. The LC module, the MS module and the computer system.
Applications[edit | edit source]
LC-MS is widely used in the field of bioanalysis and is specially involved in pharmacokinetic studies of pharmaceuticals. It is also extensively used in the metabolomics and proteomics.
See also[edit | edit source]
- Gas chromatography–mass spectrometry
- Capillary electrophoresis–mass spectrometry
- Ion mobility spectrometry–mass spectrometry
- Liquid chromatography–mass spectrometry
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
