Lisch nodule

Lisch Nodule is a hamartoma of the iris, or colored part of the eye, that is often associated with Neurofibromatosis Type 1 (NF1). These nodules are named after Austrian ophthalmologist Karl Lisch, who first described them in 1937.

Overview

Lisch nodules are small, pigmented hamartomas that occur on the surface of the iris. They are usually tan or brown in color and can vary in size and number. These nodules are benign and do not affect vision. However, they are often used as a diagnostic criterion for NF1, as they are present in over 90% of individuals with this condition by adulthood.

Symptoms

Lisch nodules themselves do not cause any symptoms. However, their presence can be an indication of NF1, which can cause a variety of symptoms including:

• Café au lait spots
• Freckling in the armpit or groin area
• Neurofibromas (benign skin tumors)
• Optic glioma (a type of brain tumor)
• Bone deformities
• Learning disabilities

Diagnosis

Lisch nodules can be detected through a simple eye examination using a slit lamp. This device allows the doctor to examine the front part of the eye, including the iris, in detail. The presence of two or more Lisch nodules in an individual over the age of six is one of the diagnostic criteria for NF1.

Treatment

As Lisch nodules are benign and do not affect vision, they do not require treatment. However, individuals with these nodules should be monitored for other signs of NF1, as this condition can have serious health implications.

See Also

• Neurofibromatosis type 1
• Hamartoma
• Iris (eye)

Lisch nodule Resources
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