List of MeSH codes (D12.644)

List of MeSH codes (D12.644) refers to a specific category within the Medical Subject Headings (MeSH) system, which is a comprehensive controlled vocabulary for the purpose of indexing journal articles and books in the life sciences. MeSH codes facilitate searching for specific topics across numerous biomedical and life science databases, including PubMed. The D12.644 series specifically categorizes peptides, which are short chains of amino acid monomers linked by peptide (amide) bonds.

Overview

Peptides are an essential topic in the field of biochemistry, molecular biology, and pharmacology, playing critical roles in biological processes and as therapeutic agents. The MeSH code D12.644 encompasses a wide range of peptides, including but not limited to, neuropeptides, oligopeptides, and polypeptides. These categories further include various specific peptides, each having unique functions and characteristics.

The D12.644 MeSH code is divided into several subcategories, each focusing on different types of peptides. Some of the notable subcategories include:

• D12.644.456 Neuropeptides - Peptides that are involved in neuronal communication. Neuropeptides act as neurotransmitters, neuromodulators, or neurohormones in the central and peripheral nervous systems. Examples include substance P, vasopressin, and neuropeptide Y.

• D12.644.641 Oligopeptides - Short peptides consisting of relatively few amino acids, typically fewer than 20. Oligopeptides include important molecules like glutathione, which plays a critical role in cellular antioxidant defenses.

• D12.644.641.500 Polypeptides - Longer chains of amino acids. Polypeptides can function independently as complete proteins or as subunits of larger protein complexes. This category includes significant hormones and enzymes that regulate various physiological processes.

• D12.644.641.700 Peptide Fragments - Fragments of peptides or proteins that are used in research or have biological activity. These fragments can be generated naturally through enzymatic processes or synthetically for research purposes.

• D12.644.641.745 Peptide Hormones - Peptides that serve as hormones, mediating various physiological functions such as metabolism, growth, and reproduction. Examples include insulin, glucagon, and growth hormone.

Importance

Understanding the structure and function of peptides is crucial for the development of new therapeutic agents and for advancing our knowledge of biological processes. Peptides have been explored as potential treatments for a wide range of diseases, including cancer, diabetes, and infectious diseases, due to their specificity and efficacy. The categorization of peptides under the MeSH code D12.644 aids researchers in locating relevant literature and advancing the field of peptide research.

See Also

• Proteins
• Amino Acids
• Biochemistry
• Pharmacology