List of aminorex analogues

Aminorex analogues are a class of stimulants that are derived from or structurally related to aminorex, a psychoactive compound with anorexigenic properties. Aminorex itself was developed in the 1960s and was found to have significant appetite suppressant effects, leading to its use for the treatment of obesity. However, due to serious side effects, including cases of pulmonary hypertension, its use was discontinued. Despite this, interest in aminorex and its analogues has persisted, particularly in the context of research into new therapeutic agents and within the realm of illicit drug manufacture.

Chemical Structure and Function

Aminorex and its analogues typically share a core phenethylamine structure, which is a common feature among many psychoactive drugs. This core is modified in various ways to produce compounds with different pharmacological properties. The modifications can affect the drug's potency, selectivity for different neurotransmitter systems (such as dopamine, norepinephrine, and serotonin), and its legal status.

List of Aminorex Analogues

• 4-Methylaminorex (4-MAR): A potent stimulant with effects similar to those of methamphetamine. It has been associated with recreational use and is illegal in many countries.
• [[5-Methylaminorex: A less well-known analogue with presumed stimulant properties.
• Para-methylaminorex (PMAR): Another analogue with limited information available regarding its effects and potency.
• [[Claminorex: A chlorine-substituted aminorex analogue, with little to no information available on its pharmacology or legality.
• [[Fluoraminorex: A fluorine-substituted analogue, again with scant information on its effects or legal status.

Legal Status and Concerns

The legal status of aminorex analogues varies by country, but many have been classified as controlled substances due to their potential for abuse and harm. The emergence of new analogues poses ongoing challenges for drug enforcement and public health agencies, as these compounds can sometimes evade existing legal regulations.

Research and Therapeutic Potential

Despite the risks associated with their use, research into aminorex analogues continues, driven by the hope of discovering compounds with beneficial therapeutic effects but without the harmful side effects of aminorex. Areas of interest include the treatment of obesity, attention deficit hyperactivity disorder (ADHD), and narcolepsy, among others.

See Also

• Phenethylamine
• Stimulant
• Appetite suppressant
• Psychoactive drug

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