List of progestogens

Progestogens are a type of steroid hormone that bind to and activate the progesterone receptor. They play a key role in the menstrual cycle and pregnancy. This article provides a list of progestogens, which are classified into generations based on their time of introduction and structural similarity.

First Generation Progestogens

The first generation progestogens include progesterone and its derivatives. They are structurally similar to the natural hormone progesterone.

• Progesterone: It is a natural hormone involved in the menstrual cycle, pregnancy, and embryogenesis.
• Medroxyprogesterone acetate: It is a derivative of progesterone and is used in hormonal contraception and hormone therapy.

Second Generation Progestogens

The second generation progestogens are derivatives of 19-nortestosterone. They have enhanced potency and reduced androgenic activity.

• Norethisterone: It is a synthetic progestogen used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders.
• Levonorgestrel: It is used in emergency contraception, intrauterine devices, contraceptive implants, and combined oral contraceptives.

Third Generation Progestogens

The third generation progestogens have improved pharmacokinetics and reduced side effects.

• Desogestrel: It is used in contraceptive pills and has less androgenic effects.
• Gestodene: It is used in contraceptive pills and has less androgenic and metabolic effects.

Fourth Generation Progestogens

The fourth generation progestogens have selective progesterone receptor modulator activity.

• Drospirenone: It is used in contraceptive pills and has antiandrogenic and antimineralocorticoid effects.
• Dienogest: It is used in contraceptive pills and for the treatment of endometriosis.

See Also

• Progesterone receptor
• Menstrual cycle
• Pregnancy
• Steroid hormone
• Hormonal contraception
• Hormone therapy

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