Lobaplatin

Lobaplatin is a third-generation platinum-based antineoplastic agent used in the treatment of various types of cancer. It was developed by ASTA Medica and is currently marketed in China under the brand name Dacin.

Chemistry

Lobaplatin is a platinum compound with the chemical formula C8H12Cl2N2O3Pt. It is a heavy, white powder that is soluble in water. The platinum atom in lobaplatin is coordinated to two chlorine atoms and a lactate molecule. The lactate molecule is responsible for the drug's unique properties and its improved toxicity profile compared to other platinum-based antineoplastic agents.

Mechanism of Action

Lobaplatin works by interfering with DNA replication in cancer cells. The platinum atom forms covalent bonds with the DNA, causing it to become cross-linked and preventing it from unwinding and replicating. This leads to cell death and the reduction of the tumor.

Clinical Use

Lobaplatin is used in the treatment of various types of cancer, including lung cancer, breast cancer, ovarian cancer, and gastric cancer. It is often used in combination with other chemotherapy drugs to increase its effectiveness.

Side Effects

Like all chemotherapy drugs, lobaplatin has a number of side effects. These can include nausea, vomiting, hair loss, and bone marrow suppression. However, lobaplatin is generally considered to have a better side effect profile than other platinum-based antineoplastic agents.

Research

Research is ongoing into the use of lobaplatin in other types of cancer and in combination with other drugs. Early results have been promising, but more research is needed to fully understand the potential of this drug.

See Also

• Platinum-based antineoplastic agent
• Chemotherapy
• Cancer

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