Lomerizine

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Lomerizine

Lomerizine is a calcium channel blocker that is primarily used in Japan for the prevention of migraine. It is not typically used in the treatment of other conditions such as hypertension or angina, which are common uses for other calcium channel blockers.

Mechanism of Action

Lomerizine works by inhibiting the influx of calcium ions into cells, which is a key step in the contraction of smooth muscle that occurs in the walls of blood vessels. By preventing this contraction, lomerizine can help to prevent the narrowing of blood vessels that is thought to contribute to the development of migraines.

Pharmacokinetics

After oral administration, lomerizine is rapidly absorbed from the gastrointestinal tract. It is extensively metabolized in the liver, primarily by the cytochrome P450 enzyme system. The half-life of lomerizine is approximately 12 hours, allowing for once-daily dosing.

Side Effects

Common side effects of lomerizine include dizziness, nausea, and fatigue. Less common but more serious side effects can include heart palpitations, hypotension, and syncope.

Contraindications

Lomerizine should not be used in individuals with known hypersensitivity to the drug. It should also be used with caution in individuals with liver disease or heart disease, as these conditions can affect the metabolism and efficacy of the drug.

Interactions

Lomerizine can interact with other medications, including other calcium channel blockers and CYP3A4 inhibitors. These interactions can increase the risk of side effects and decrease the effectiveness of lomerizine.

See Also

• Calcium channel blocker
• Migraine
• Pharmacokinetics
• Pharmacodynamics